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肖毅

姓 名

肖毅

说明: 430124198803208394 (188号 肖毅)+遵义医学院.JPG

性 别

年龄

33

通讯地址

贵州省遵义市新蒲新区学府西路6号

邮 编

563000

邮 箱

470642493@qq.com

职 称

副高,硕士生导师

职 务

简 介

中国共产党党员、博士、硕士生导师。主要从事肿瘤分子生物学,天然免疫及抗衰老分子机制研究和新药研发。先后主持国家自然科学基金、遵义市科技计划基金等3项。近5年,以第一作者或通讯作者(含共同)Aging CelliScienceInt Immunopharmacol Virulence等杂志上发表SCI收录论文12篇;并被同行广泛引用(包括被发表Nature Immunology, Cell Mol Biol Lett, Oncoimmunology等高水平杂志的论文所引用)。

教育背景

云南大学,微生物专业,博士

学术组织任职

主讲课程

《科技论文绘图技术》与《科技论文绘图技术与配图解析》

科研项目

1.国家自然科学基金,去乙酰化酶HDA-1/HDAC1通过内质网应激信号途径促进天然免疫的分子机制研究,2021.01-2024.1234万元,主持。

2.国家自然科学基金,同源盒转录因子CEH-37/OTX2通过P38 MAPK信号途径促进天然免疫的分子机制研究,2022.01-2025.1234万元,主研。

3.国家自然科学基金,蟾皮单体Argentinogenin通过STAT3-CPT1B介导肝癌细胞脂质代谢失衡抑制肿瘤转移的机制研究,2022.01-2025.1234万元,主研。

发表论文

1. Yi Xiao#, Fang Liu#, Qinghong Kong, Xinting Zhu, Haijuan Wang, Sanhua Li, Nian Jiang,Changyan Yu, Yun Liu*. Metformin induces S-adenosylmethionine restriction to extend the Caenorhabditis elegans healthspan through H3K4me3 modifiers[J]. Aging Cell, 2022: e13567. (IF=11.005), JCR一区(一区)

2. Fang Liu#, Haijuan Wang#, Xinting Zhu#,Nian Jiang, Feng Pan, Changwei Song, Chunbo Yu, Changyan Yu,Ying Qin, Jing Hui, Sanhua Li, Yi Xiao*, Yun Liu*. Sanguinarine promotes healthspan and innate immunity through a conserved mechanism of ROS-mediated PMK-1/SKN-1 activation[J]. iScience, 2022, 25(3):103874. (IF= 6.107), JCR一区(二区)

3. Yi Xiao#, Huiling Zhang#, Yi Sheng#, Fang Liu, Jiajun Gao, Guosheng Liu, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu*. Usnic Acid extends healthspan and improves the neurodegeneration diseases via mTOR/PHA-4 signaling pathway in Caenorhabditis elegans[J]. iScience, 2022. (IF= 6.107), JCR一区(二区)

4. Yi Xiao#*, Fang Liu#, Xinting Zhu #, Sanhua Li#, Lingjie Meng, Nian Jiang, Changyan Yu, Haijuan Wang, Ying Qin, Jing Hui, Chunbo Yu, Yun Liu*. Dioscin integrates regulation of monosaturated fatty acid metabolism to extend the life span through XBP-1/SBP-1 dependent manner[J]. iScience, 2023. (IF= 6.107), JCR一区(二区)

5. Yi Xiao#, Li Zhang#, Xinting Zhu, Ying Qin, Changyan Yu, Nian Jiang, Sanhua Li, Fang Liu*, Yun Liu*. Luteolin promotes pathogen resistance in Caenorhabditis elegans via DAF-2/DAF-16 insulin-like signaling pathway[J]. Int Immunopharmacol 2023;115:109679. (IF= 5.714), JCR一区(二区)

6. Xinting Zhu#, Fang Liu#, Qinyi Wu#, Sanhua Li, Guoyong Ruan, Jianbo Yang, Changyan Yu, Nian Jiang, Yi Xiao*, Yun Liu*. Brevilin A enhances innate immunity and the resistance of oxidative stress in Caenorhabditis elegans via p38 MAPK pathway[J]. Int Immunopharmacol 2022;113:109385. (IF= 5.714), JCR一区(二区)

7. Yi Xiao#, Fang Liu#, Sanhua Li, Nian Jiang, Changyan Yu, Xinting Zhu, Ying Qin, Jing Hui, Lingjie Meng, Changwei Song, Xiaofei Li*,Yun Liu*. Metformin promotes innate immunity through a conserved PMK-1/p38 MAPK pathway[J].Virulence, 2020, 11(1): 39-48.(IF= 5.428), JCR一区(二区)

8. Yi Xiao#, Qiang Gong#, Wenhong Wang#, Fang Liu, Qinghong Kong, Feng Pan, Xiaoke Zhang, Changyan Yu, Shanshan Hu, Fang Fan, Sanhua Li*,Yun Liu*. The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma[J]. Cancer Cell International, 2020,20(1):371.(IF= 6.429), JCR二区(二区)

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