肖毅

 

    

肖毅

 

    

通讯地址

贵州省遵义市新蒲新区校园1号路

    

563000

    

xiaoyizmu@126.com

    

副高,硕士生导师

    

中国共产党党员、博士、副高、硕士研究生导师、临床医学南山班导师、口腔医学卓越班导师。best365英国体育在线教工第十二党支部书记。贵州省高层次创新型人才培养计划层次入选者。贵州省第一批科技专家库入库专家。贵州省药品监督管理局化妆品技术核查咨询专家库专家。best365英国体育在线优秀教师(2023)。best365英国体育在线基础医学优秀本科生指导老师。主要从事肿瘤分子生物学、天然免疫及抗衰老分子机制研究和新药研发。先后主持国家自然科学基金、贵州省科技计划重点项目等5项、主研国家自然科学基金2项、贵州省科技支撑计划项目2项。近5年,以第一作者或通讯作者(含共同)Aging Cell, Cellular and Molecular Life Sciences, Journal of Infectious Diseases, iScience, STAR Protocols, Int Immunopharmacol, Virulence等国际知名杂志上发表SCI收录论文25篇,并被同行广泛引用(包括被发表Nature Immunology, elife, Cell Mol Biol Lett, Oncoimmunology等高水平杂志的论文所引用)。目前为Aging Cell, Journal of Advanced Research, Phytotherapy Research, Aging and Disease, iScience, STAR Protocols, Int Immunopharmacol, Oncoimmunology, Immunity & Ageing20多种SCI期刊的审稿人。

教育背景

云南大学,微生物学专业,博士

主讲课程

《科研方法与实验技术》 《科技论文绘图技术》

科研项目

1.国家自然科学基金,去乙酰化酶HDA-1/HDAC1通过内质网应激信号途径促进天然免疫的分子机制研究,2021.01-2024.1234万元,主持。

2.贵州省科技计划项目(重点项目),大黄酚通过胰岛素信号途径 DAF-2IGF-1R/DAF-16FOXO3A)抗衰老的分子机制研究,2024.04-2028.0430万元,主持。

3.遵义市工业与科学技术局best365英国体育在线联合基金(重点项目),银杏内酯A通过线粒体未折叠蛋白反应信号通路抗衰老的分子机制研究,2024.11-2026.1130万元,主持。

4.国家自然科学基金,同源盒转录因子CEH-37/OTX2通过P38 MAPK信号途径促进天然免疫的分子机制研究,2022.01-2025.1234万元,主研。

5.国家自然科学基金,蟾皮单体Argentinogenin通过STAT3-CPT1B介导肝癌细胞脂质代谢失衡抑制肿瘤转移的机制研究,2022.01-2025.1234万元,主研。

6.贵州省科技支撑计划项目,岩果止咳液中具有止咳功效物质基础的发现及质量标准提升的研究,2022.12-2026.1267万元,主研。

7.贵州省科技支撑计划项目,基于中药注射剂华蟾素深度挖掘的小分子抗结肠癌药物开发研究,2020.12-2023.1240万元,主研。

发表论文

3年部分代表性论文如下:

1.Yi Xiao#(第一作者), Fang Liu#, Qinghong Kong, Xinting Zhu, Haijuan Wang, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu*. Metformin induces S-adenosylmethionine restriction to extend the Caenorhabditis elegans healthspan through H3K4me3 modifiers [J]. Aging Cell, 2022: e13567. (IF=11发表当年), JCR一区(一区top)

2.Fang Liu#, Hongjiao Zhang#, Haijuan Wang#, Xinting Zhu, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu*, Yi Xiao*(通讯作者). The homeodomain transcription factor CEH-37 regulates PMK-1/p38 MAPK pathway to protect against intestinal infection via the phosphatase VHP-1 [J]. Cell Mol Life Sci. 2023 Oct 5;80(11):312. (IF= 8发表当年), JCR一区(一区top)

3.Yi Xiao#*(第一作者兼通讯作者), Fang Liu#, Qinyi Wu#, Xinting Zhu, Changyan Yu, Nian Jiang, Sanhua Li, Yun Liu*. Dioscin activates endoplasmic reticulum UPR for defense against pathogen bacteria in Caenorhabditis elegans via IRE-1/XBP-1 pathway [J]. Journal of Infectious Diseases, 2024 Jan 12; 229(1):237-244. (IF= 6.4发表当年), JCR一区(二区top)

4.Yi Xiao#*(第一作者兼通讯作者), Hanlin Zhou#, Yingwen Cui#, Xinting Zhu, Sanhua Li, Changyan Yu, Nian Jiang, Liu Liu*, Fang Liu*. Schisandrin A enhances pathogens resistance by targeting a conserved p38 MAPK pathway [J]. Int Immunopharmacol. 2024 Jan 3;128:111472. (IF= 5.7发表当年), JCR一区(二区top)

5.Fang Liu#, Haijuan Wang#, Xinting Zhu#, Nian Jiang, Feng Pan, Changwei Song, Chunbo Yu, Changyan Yu, Ying Qin, Jing Hui, Sanhua Li, Yi Xiao*(通讯作者), Yun Liu*. Sanguinarine promotes healthspan and innate immunity through a conserved mechanism of ROS-mediated PMK-1/SKN-1 activation [J]. iScience, 2022, 25(3):103874. (IF= 6.1发表当年), JCR一区(二区)

6.Yi Xiao#*(第一作者兼通讯作者), Li Zhang#, Yu Liu*. Protocol for assessing the healthspan of Caenorhabditis elegans after potential anti-aging drug treatment. STAR Protoc. 2023 May 5;4(2):102285.

7.Yi Xiao#(第一作者), Huiling Zhang#, Yi Sheng#, Fang Liu, Jiajun Gao, Guosheng Liu, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu*. Usnic Acid extends healthspan and improves the neurodegeneration diseases via mTOR/PHA-4 signaling pathway in Caenorhabditis elegans [J]. iScience, 2022 Nov 9;25(12):105539. (IF= 6.1发表当年), JCR一区(二区)

8.Yi Xiao#*(第一作者兼通讯作者), Fang Liu#, Xinting Zhu #, Sanhua Li#, Lingjie Meng, Nian Jiang, Changyan Yu, Haijuan Wang, Ying Qin, Jing Hui, Chunbo Yu, Yun Liu*. Dioscin integrates regulation of monosaturated fatty acid metabolism to extend the life span through XBP-1/SBP-1 dependent manner [J]. iScience, 2023 Feb 24;26(3):106265. (IF= 6.1发表当年), JCR一区(二区)

9.Yi Xiao#(第一作者), Li Zhang#, Xinting Zhu, Ying Qin, Changyan Yu, Nian Jiang, Sanhua Li, Fang Liu*, Yun Liu*. Luteolin promotes pathogen resistance in Caenorhabditis elegans via DAF-2/DAF-16 insulin-like signaling pathway [J]. Int Immunopharmacol 2023;115:109679. (IF= 5.7发表当年), JCR一区(二区top)

10. Xinting Zhu#, Fang Liu#, Qinyi Wu#, Sanhua Li, Guoyong Ruan, Jianbo Yang, Changyan Yu, Nian Jiang, Yi Xiao*(通讯作者), Yun Liu*. Brevilin A enhances innate immunity and the resistance of oxidative stress in Caenorhabditis elegans via p38 MAPK pathway [J]. Int Immunopharmacol 2022;113:109385. (IF= 5.7发表当年), JCR一区(二区top)

11.Yi Xiao#(第一作者), Fang Liu#, Sanhua Li, Nian Jiang, Changyan Yu, Xinting Zhu, Ying Qin, Jing Hui, Lingjie Meng, Changwei Song, Xiaofei Li*,Yun Liu*. Metformin promotes innate immunity through a conserved PMK-1/p38 MAPK pathway [J].Virulence, 2020, 11(1): 39-48.(IF= 5.8发表当年), JCR一区(一区top)

12.Yi Xiao#(第一作者), Qiang Gong#, Wenhong Wang#, Fang Liu, Qinghong Kong, Feng Pan, Xiaoke Zhang, Changyan Yu, Shanshan Hu, Fang Fan, Sanhua Li*,Yun Liu*. The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma [J]. Cancer Cell International, 2020,20(1):371.(IF= 6.4发表当年), JCR二区(二区)

13. Yi Xiao#*(第一作者兼通讯作者), Chao Han#, Xiaocong Li#, Xinting Zhu, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu*, Fang Liu*. S-Adenosylmethionine (SAM) diet promotes innate immunity via histone H3K4me3 complex [J]. Int Immunopharmacol. 2024 Mar 11;131:111837. (IF= 5.7发表当年), JCR一区(二区top)

14. Yi Xiao#*(第一作者兼通讯作者), Hongjiao Zhang#, Xiaocong Li#, Chao Han#, Fang Liu*.DEADbox RNA helicase DDX23 mediates dietary restriction induced health span in Caenorhabditis elegans [J]. GeroScience. 2024. (IF= 5.6发表当年), JCR一区(二区top)

15. Nian Jiang#, Sanhua Li#, Lingjie Meng, Yao Zhang, Changyan Yu, Yi Xiao*(通讯作者), Yun Liu*. Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3 [J]. Eur J Pharmacol. 2024 Mar 5;966:176372. (IF= 5发表当年), JCR一区(二区top)

 

 

 

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